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clomipramine decreases outcomes of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Prevents conversion of codeine to its active metabolite morphine.
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copyright topical decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on. Helps prevent conversion of codeine to its Lively metabolite morphine.
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In nursing moms that are “ultrafast CYP2D6 metabolizers” and get codeine therapy, the chance of overdose and Loss of life from the new child on account of a large morphine serum focus is superior. In the case more info of signs of opioid toxicity, shut monitoring of sufferers is of enormous relevance.
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Gli oppioidi agiscono legandosi agli specifici recettori (recettori degli oppioidi), che si trovano principalmente nel sistema nervoso read more centrale e periferico e nel tratto gastrointestinale.